The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey and Kieran Kennedy discuss how vascular dysfunction drives joint degeneration and muscle loss.

Dave Asprey explains that focus is a chemical state driven by norepinephrine and dopamine, which are depleted by chronic stress, poor sleep, and sedentary habits.

Dave Asprey explores how chronic infections like H.

Dave Asprey discusses the scientific basis of consciousness with professional psychic and medical device inventor Julie Ryan.

Cora Organic founder shares how her mother’s cancer diagnosis inspired her to create a certified organic skincare brand, emphasizing that skin absorbs what we apply.

Dave Asprey shares his journey from being 300 pounds to peak health by debunking conventional diet advice.

Dave Asprey covers recent biohacking research, including a trial showing ear-based vagus nerve stimulation may improve memory in mild cognitive impairment.

Dave Asbury interviews Young Goose co-founders Amate and Anastasia on longevity-focused skincare, emphasizing that wrinkles are symptoms of underlying cellular decline.

Host Dave Asprey and Sigi Clavian of Deliverance discuss liver health, explaining that 100 million Americans have undiagnosed fatty liver disease due to poor blood panel detection.

Host Dave Asprey outlines six simple, affordable biohacking methods to reduce visceral fat, prioritizing stress reduction to lower cortisol.

Dave Asprey explores Novo Nordisk’s potential entry into hair loss treatments and the rapid evolution of follicle-reactivating drugs.

Dr.

Dave Asbury interviews Catherine, a 70-year-old algae expert and founder of Energy Bits, to discuss the longevity benefits of microalgae.

Host Dave Asprey shares his personal recovery from mold-induced brain damage, explaining how mycotoxins disrupt mitochondria and cause chronic symptoms like fatigue and brain fog.

Dave Asprey interviews Teal Swan, a spiritual practitioner with extrasensory abilities, discussing her unique perception of reality and the nature of ego.

Dr.

Dave Asprey and actor Josh Jamison discuss biohacking, longevity, and the importance of hormone optimization for men and women.

Dave Asprey and Carolina Reyes de Oliveira discuss One Skin’s new rich moisturizer, designed to combat age-related dehydration and menopause-related skin thinning.

This episode details the hour-by-hour physiological changes that occur when you cut sugar for 36 hours, explaining how insulin levels drop to unlock fat storage and reduce inflammation.

Dave Asprey covers recent biohacking news, starting with research showing sea squirt plasmalogens reversed aging signs in mice.

Dr.

Dave Asprey discusses a top weight loss doctor’s three-step protocol for losing 50 pounds by addressing insulin resistance.

Dave Asprey analyzes raw garlic’s benefits and cognitive downsides, advocates for HEPA filtration to reduce neuroinflammation, and highlights protective egg yolk peptides.

Dave Asprey interviews Jenny, a mother who reversed her son’s autism diagnosis through dietary changes and detoxification after a severe reaction to the MMR vaccine.

Dave Asprey critiques popular longevity drugs like metformin, rapamycin, and statins, arguing they blunt regeneration or lack human data.

Host Dave Asprey shares seven underrated supplements to boost brain energy and longevity, drawing from his personal biohacking journey.

Dave Asprey interviews Hal Elrod, author of The Miracle Morning, about his updated book and the philosophy behind the morning routine.

Dave Asprey hosts Johnny Miller to discuss nervous system mastery, interoception, and emotional fluidity as critical components of longevity.

Dave Asprey interviews memory expert Jim Quick about leveraging AI to enhance, rather than replace, human intelligence.

Dave Asprey explains how declining NAD+ levels drive aging and energy loss, citing Nobel Prize research on its role in cognitive health.

Dave Asprey interviews Gurudev Sri Sri Ravi Shankar live at the Art of Living Center, discussing breathwork, spirituality, and biohacking.

Dave Asprey interviews Patrick Coles on his Toxin Sequestration Theory, which posits that chronic diseases and cancer are defense mechanisms against toxic overload rather than genetic failures.

Dave Asprey discusses biohacking mitochondria to enhance longevity, performance, and spiritual perception, linking quantum biology to reality creation.

Dave Asprey explains how modern stress and eating habits suppress mitophagy, the cellular cleanup process essential for longevity.

Dave Asprey reviews biohacking news, including an inhaled Alzheimer’s drug trial, regenerative brain cells, and keratin bone scaffolds.

Dave Asprey explores racetams, the original nootropics, detailing their history, mechanisms, and benefits for memory, focus, and neuroprotection.

Dave Asprey interviews Dr.

Dave Asprey explains why glutathione, the "master antioxidant," is crucial for combating oxidative stress and skin aging, rather than just boosting collagen.

Dave Asprey reviews recent longevity research, highlighting oxymetazoline’s potential anti-aging effects and protein restriction’s impact on metabolic health via FGF21.

Dave Asprey interviews a guest who credits orgasm with healing her childhood trauma by triggering neurochemical shifts from fight-or-flight to rest-and-repair.

Dave Asprey interviews Dr.

Host Dave Asprey explores glutathione, the body’s master antioxidant, as a key longevity hack.

Dave Asprey reviews recent studies on sildenafil’s potential to block cancer metastasis, the cognitive risks of passive TV watching, and how chronic heat accelerates biological aging.

Dave Asprey interviews urologist Dr.

Dave Asprey introduces "sleep fasting," a biohack involving stopping food intake three hours before bed to lower cortisol and enable deep sleep repair.

Dave Asprey discusses new research linking artificial sweeteners to accelerated cognitive decline and highlights myosteatosis as a key predictor of cardiovascular risk beyond calcium scores.

Dave Asprey interviews microbiologist Kieran Krishnan on using spore-based probiotics to restore gut diversity and boost butyrate production for longevity.

Host Dave Asprey and guest Dr.

Dave Asprey outlines an affordable biohacking stack under $200 to enhance longevity and performance.