The Human Upgrade: Biohacking for Longevity & Performance

Host Dave Asprey explores glutathione, the body’s master antioxidant, as a key longevity hack.

Dave Asprey reviews recent studies on sildenafil’s potential to block cancer metastasis, the cognitive risks of passive TV watching, and how chronic heat accelerates biological aging.

Dave Asprey interviews urologist Dr.

Dave Asprey introduces "sleep fasting," a biohack involving stopping food intake three hours before bed to lower cortisol and enable deep sleep repair.

Dave Asprey discusses new research linking artificial sweeteners to accelerated cognitive decline and highlights myosteatosis as a key predictor of cardiovascular risk beyond calcium scores.

Dave Asprey interviews microbiologist Kieran Krishnan on using spore-based probiotics to restore gut diversity and boost butyrate production for longevity.

Host Dave Asprey and guest Dr.

Dave Asprey outlines an affordable biohacking stack under $200 to enhance longevity and performance.

Dave Asprey interviews Sean Stevenson on The Human Upgrade, exploring how communal family meals boost longevity and nervous system regulation.

Dave Asprey hosts pharmacist Dr.

Dave Asprey interviews Dr.

Dave Asprey explains how spermidine, found in Japanese natto, triggers autophagy to reverse aging and boost longevity.

Dave Asprey interviews Jordan Harbinger, who shares how he escaped two kidnappings using charm and logic.

Dave Asprey hosts Dr.

Dave Asprey interviews Brian Richards, founder of Sauna Space, on using near-infrared light therapy to counteract the cellular damage caused by modern LED blue light.

Dave Asprey explains how to optimize brain energy and focus by stacking specific compounds rather than relying on willpower.

Dave Asprey reviews recent biohacking research, highlighting gut acetate’s role in brain health and the importance of dietary fiber.

Dave Asprey and Ben Azadi discuss biohacking strategies, including a 90-day carnivore experiment, creatine absorption hacks, and the importance of metabolic flexibility.

Dr.

Dave Asprey explains how NAD+ levels dictate aging and energy, citing Nobel Prize research on cognitive decline.

Dave Asprey debunks myths about fish oil and the DASH diet, emphasizing foundational health over isolated supplements.

Dave Asprey interviews the founder of MTE, a caffeine-free energy drink designed to provide calm, focused energy without disrupting sleep or cortisol levels.

Dave Asprey interviews Dubai-based longevity strategist Dr.

Host Dave Asprey explains how modern lifestyle factors suppress mitophagy, the cellular process that recycles damaged mitochondria.

Host Dave Asprey reviews five health studies, challenging common beliefs about Alzheimer’s, diet, and supplements.

Dave Asprey interviews Dr.

Dave Asprey interviews dermatologist Dr.

Host Dave Asprey argues that focus loss stems from brain chemistry, not lack of discipline, specifically depleted neurotransmitters and oxidative stress.

Dave Asprey analyzes recent health news, highlighting semaglutide’s impact on aging clocks and the FDA’s approval of Bimotrazinol sunscreen.

Dr.

Host Dave Asprey interviews functional medicine physician Dr.

Dave Asprey recounts how drinking yak butter tea in Tibet inspired his "Bulletproof Coffee" method, leading to significant weight loss and improved energy.

Dave Asprey discusses engineered viruses showing promise against pancreatic cancer and the risks of teens relying on AI chatbots for mental health.

Andrew Huberman hosts Dr.

Dave Asprey interviews Justin Kirkland of Amino Innovations about peptide safety, synthesis, and administration.

Dave Asprey argues that brain fog often stems from poor circulation and sensory deprivation caused by modern footwear, not just mental fatigue.

Dave Asprey reviews the Enhanced Games, Kyle Busch’s death from sepsis, and new research linking menin to aging and inflammation to depression.

Host Dave Asprey interviews Dr.

Dave Asprey interviews Dr.

This episode explores five longevity habits from Okinawa’s Blue Zone, featuring insights from host Dave Asprey.

Dave Asprey interviews Dr.

Dave Asprey interviews Chris Wrench, co-founder of Timeline, about their discovery of Urolithin A, a compound that triggers mitophagy to improve mitochondrial function.

Dave Asprey and Dr.

Host Dave Asprey explains how to stack L-theanine with caffeine to achieve calm, monk-like focus by balancing beta and alpha brainwaves.

Dave Asprey reviews five biohacking stories, including creatine’s benefits for sleep-deprived cognition and microplastics in gum.

This episode features a longevity expert discussing why walking alone is insufficient for health after 50, advocating instead for resistance training to combat muscle loss and bone density decline.

Dave Asprey interviews relationship expert John Gray, who shares biohacking insights on hormones, longevity, and relationships.

Dave Asprey discusses the Fasting Mimicking Diet, a five-day protocol designed to trigger autophagy and gut repair while allowing limited food intake.

Dave Asprey discusses new research linking normal testosterone levels to reduced brain tumor growth and warns of CDC rabies testing delays.