The Human Upgrade: Biohacking for Longevity & Performance

Dr.

Dave Asprey and actor Josh Jamison discuss biohacking, longevity, and the importance of hormone optimization for men and women.

Dave Asprey and Carolina Reyes de Oliveira discuss One Skin’s new rich moisturizer, designed to combat age-related dehydration and menopause-related skin thinning.

This episode details the hour-by-hour physiological changes that occur when you cut sugar for 36 hours, explaining how insulin levels drop to unlock fat storage and reduce inflammation.

Dave Asprey covers recent biohacking news, starting with research showing sea squirt plasmalogens reversed aging signs in mice.

Dr.

Dave Asprey discusses a top weight loss doctor’s three-step protocol for losing 50 pounds by addressing insulin resistance.

Dave Asprey analyzes raw garlic’s benefits and cognitive downsides, advocates for HEPA filtration to reduce neuroinflammation, and highlights protective egg yolk peptides.

Dave Asprey interviews Jenny, a mother who reversed her son’s autism diagnosis through dietary changes and detoxification after a severe reaction to the MMR vaccine.

Dave Asprey critiques popular longevity drugs like metformin, rapamycin, and statins, arguing they blunt regeneration or lack human data.

Host Dave Asprey shares seven underrated supplements to boost brain energy and longevity, drawing from his personal biohacking journey.

Dave Asprey interviews Hal Elrod, author of The Miracle Morning, about his updated book and the philosophy behind the morning routine.

Dave Asprey hosts Johnny Miller to discuss nervous system mastery, interoception, and emotional fluidity as critical components of longevity.

Dave Asprey interviews memory expert Jim Quick about leveraging AI to enhance, rather than replace, human intelligence.

Dave Asprey explains how declining NAD+ levels drive aging and energy loss, citing Nobel Prize research on its role in cognitive health.

Dave Asprey interviews Gurudev Sri Sri Ravi Shankar live at the Art of Living Center, discussing breathwork, spirituality, and biohacking.

Dave Asprey interviews Patrick Coles on his Toxin Sequestration Theory, which posits that chronic diseases and cancer are defense mechanisms against toxic overload rather than genetic failures.

Dave Asprey discusses biohacking mitochondria to enhance longevity, performance, and spiritual perception, linking quantum biology to reality creation.

Dave Asprey explains how modern stress and eating habits suppress mitophagy, the cellular cleanup process essential for longevity.

Dave Asprey reviews biohacking news, including an inhaled Alzheimer’s drug trial, regenerative brain cells, and keratin bone scaffolds.

Dave Asprey explores racetams, the original nootropics, detailing their history, mechanisms, and benefits for memory, focus, and neuroprotection.

Dave Asprey interviews Dr.

Dave Asprey explains why glutathione, the "master antioxidant," is crucial for combating oxidative stress and skin aging, rather than just boosting collagen.

Dave Asprey reviews recent longevity research, highlighting oxymetazoline’s potential anti-aging effects and protein restriction’s impact on metabolic health via FGF21.

Dave Asprey interviews a guest who credits orgasm with healing her childhood trauma by triggering neurochemical shifts from fight-or-flight to rest-and-repair.

Dave Asprey interviews Dr.

Host Dave Asprey explores glutathione, the body’s master antioxidant, as a key longevity hack.

Dave Asprey reviews recent studies on sildenafil’s potential to block cancer metastasis, the cognitive risks of passive TV watching, and how chronic heat accelerates biological aging.

Dave Asprey interviews urologist Dr.

Dave Asprey introduces "sleep fasting," a biohack involving stopping food intake three hours before bed to lower cortisol and enable deep sleep repair.

Dave Asprey discusses new research linking artificial sweeteners to accelerated cognitive decline and highlights myosteatosis as a key predictor of cardiovascular risk beyond calcium scores.

Dave Asprey interviews microbiologist Kieran Krishnan on using spore-based probiotics to restore gut diversity and boost butyrate production for longevity.

Host Dave Asprey and guest Dr.

Dave Asprey outlines an affordable biohacking stack under $200 to enhance longevity and performance.

Dave Asprey interviews Sean Stevenson on The Human Upgrade, exploring how communal family meals boost longevity and nervous system regulation.

Dave Asprey hosts pharmacist Dr.

Dave Asprey interviews Dr.

Dave Asprey explains how spermidine, found in Japanese natto, triggers autophagy to reverse aging and boost longevity.

Dave Asprey interviews Jordan Harbinger, who shares how he escaped two kidnappings using charm and logic.

Dave Asprey hosts Dr.

Dave Asprey interviews Brian Richards, founder of Sauna Space, on using near-infrared light therapy to counteract the cellular damage caused by modern LED blue light.

Dave Asprey explains how to optimize brain energy and focus by stacking specific compounds rather than relying on willpower.

Dave Asprey reviews recent biohacking research, highlighting gut acetate’s role in brain health and the importance of dietary fiber.

Dave Asprey and Ben Azadi discuss biohacking strategies, including a 90-day carnivore experiment, creatine absorption hacks, and the importance of metabolic flexibility.

Dr.

Dave Asprey explains how NAD+ levels dictate aging and energy, citing Nobel Prize research on cognitive decline.

Dave Asprey debunks myths about fish oil and the DASH diet, emphasizing foundational health over isolated supplements.

Dave Asprey interviews the founder of MTE, a caffeine-free energy drink designed to provide calm, focused energy without disrupting sleep or cortisol levels.

Dave Asprey interviews Dubai-based longevity strategist Dr.