The Human Upgrade: Biohacking for Longevity & Performance The Human Upgrade: Biohacking for Longevity & Performance

The Most Important Longevity Molecule I've Ever Found : 1524

Aug 23, 2026 · 14m

Summary

Dave Asprey explains how declining NAD+ levels drive aging and energy loss, citing Nobel Prize research on its role in cognitive health. He outlines a protocol to restore NAD+ by consuming niacin and tryptophan, using quercetin and apigenin to inhibit breakdown, and triggering production via fasting and high-intensity exercise. Finally, he recommends specific NAD+ precursor supplements like NMN or NR to complete the regimen.

Topics discussed

Echo Flask: Hydrogen-infused water for energy and recovery The NAD+ molecule: The key to aging and cellular energy NAD+ levels and cognitive decline: Alzheimer's research insights Mitopure: Urolithin A for mitochondrial renewal and strength Reversing cognitive decline: Animal study results on NAD+ iRestore: Red light therapy for hair growth and skin health Viome: Personalized nutrition based on RNA analysis Why NAD+ supplements often fail without a proper protocol Dietary foundations: Niacin, tryptophan, quercetin, and apigenin Fasting and AMPK: Triggering NAD+ production signals REHIT exercise: High-intensity intervals for mitochondrial health Supplementation strategy: NMN and NR dosing for NAD+ boost Podcast credits and medical disclaimers
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