Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537
Sep 16, 2026 · 55m
Summary
Dave Asprey and actor Josh Jamison discuss biohacking, longevity, and the importance of hormone optimization for men and women. They explore the benefits of testosterone and HRT, debunking myths about side effects and the necessity of medical supervision. The conversation also covers the spiritual and mental health impacts of breathwork and psychedelics, as well as practical parenting tips like natural elimination communication.
Topics discussed
Intro: Feeling stronger and the Human Upgrade
Sponsor: Modafinil and Mod
Sponsor: Omnibiotic probiotics
Guest intro: Josh James and Gatling Health
Health shifts in entertainment and diet
Food sensitivity, kids, and nutrition choices
Alcohol, supplements, and Burning Man
Ayahuasca experiences and safety concerns
Quantum reality, breathwork, and spiritual connection
Spirituality, church, and handling bad trips
Online trolls and personal resilience
Starting with the body and testosterone branding
Sponsor: Timeline mitochondria support
Sponsor: Kinetic ketones
Testosterone therapy history and benefits
Hormone replacement for women and menopause
Myths about testosterone and self-regulation
Josh's low T story and public perception
Gatling Health model and peptide guidance
Testosterone dosing, injection vs. cream
Life changes, parenting, and baby smell
Natural elimination communication and potty training
Birth rates, longevity, and having kids at 53
Myths about stopping testosterone
Sponsor: iRestore hair and skin
Life choices, sacrifice, and family dynamics
Sibling age gaps and Fargo vs. Moorhead
Sourcing peptides and supply chain security
Personal responsibility in healthcare decisions
Supplement regulation history and access
Cosmetic procedures and GLP-1 caution
Low-dose GLP-1 for longevity
Synergy of hormones, gym, and spirituality
Wasted money on health and stem cells
Time perception and friend group dynamics
Acting career, stage fright, and memory
Nootropics: Aniracetam and Modafinil
Cognitive resilience and ADHD/Autism
Optimization for longevity and dark forces
Call to action: Check testosterone levels
Medical disclaimer and podcast ownership
Listen ad-free on Castria