The Human Upgrade: Biohacking for Longevity & Performance The Human Upgrade: Biohacking for Longevity & Performance

It's Weird, But It Turns On Your Anti-Aging Switch : 1520

Aug 16, 2026 · 15m

Summary

Dave Asprey explains how modern stress and eating habits suppress mitophagy, the cellular cleanup process essential for longevity. He outlines a protocol to reactivate this switch using fasting, high-intensity exercise, and cold exposure. Additionally, he recommends boosting NAD+ levels with NMN or NR supplements and adding urolithin A and spermidine to support mitochondrial health and repair.

Topics discussed

Sponsors: Predictive Mind and Mohonk Mountain House The longevity switch and mitochondrial health Understanding mitophagy and cellular cleanup How stress, diet, and exercise suppress mitophagy Sponsor: Sunlighten Infrared Sauna NAD+ decline and Sponsor: Viome Sponsor: iRestore Red Light Therapy The cycle of inflammation and biological aging Activating mitophagy through fasting High-intensity exercise and REHIT protocol Cold exposure and NAD+ supplementation Urolithin A and Spermidine for cellular cleanup Conclusion and podcast disclaimer
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