It's Weird, But It Turns On Your Anti-Aging Switch : 1520
Aug 16, 2026 · 15m
Summary
Dave Asprey explains how modern stress and eating habits suppress mitophagy, the cellular cleanup process essential for longevity. He outlines a protocol to reactivate this switch using fasting, high-intensity exercise, and cold exposure. Additionally, he recommends boosting NAD+ levels with NMN or NR supplements and adding urolithin A and spermidine to support mitochondrial health and repair.
Topics discussed
Sponsors: Predictive Mind and Mohonk Mountain House
The longevity switch and mitochondrial health
Understanding mitophagy and cellular cleanup
How stress, diet, and exercise suppress mitophagy
Sponsor: Sunlighten Infrared Sauna
NAD+ decline and Sponsor: Viome
Sponsor: iRestore Red Light Therapy
The cycle of inflammation and biological aging
Activating mitophagy through fasting
High-intensity exercise and REHIT protocol
Cold exposure and NAD+ supplementation
Urolithin A and Spermidine for cellular cleanup
Conclusion and podcast disclaimer
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