The Human Upgrade: Biohacking for Longevity & Performance

Host Dave Asprey explains how modern lifestyle factors suppress mitophagy, the cellular process that recycles damaged mitochondria.

Host Dave Asprey reviews five health studies, challenging common beliefs about Alzheimer’s, diet, and supplements.

Dave Asprey interviews Dr.

Dave Asprey interviews dermatologist Dr.

Host Dave Asprey argues that focus loss stems from brain chemistry, not lack of discipline, specifically depleted neurotransmitters and oxidative stress.

Dave Asprey analyzes recent health news, highlighting semaglutide’s impact on aging clocks and the FDA’s approval of Bimotrazinol sunscreen.

Dr.

Host Dave Asprey interviews functional medicine physician Dr.

Dave Asprey recounts how drinking yak butter tea in Tibet inspired his "Bulletproof Coffee" method, leading to significant weight loss and improved energy.

Dave Asprey discusses engineered viruses showing promise against pancreatic cancer and the risks of teens relying on AI chatbots for mental health.

Andrew Huberman hosts Dr.

Dave Asprey interviews Justin Kirkland of Amino Innovations about peptide safety, synthesis, and administration.

Dave Asprey argues that brain fog often stems from poor circulation and sensory deprivation caused by modern footwear, not just mental fatigue.

Dave Asprey reviews the Enhanced Games, Kyle Busch’s death from sepsis, and new research linking menin to aging and inflammation to depression.

Host Dave Asprey interviews Dr.

Dave Asprey interviews Dr.

This episode explores five longevity habits from Okinawa’s Blue Zone, featuring insights from host Dave Asprey.

Dave Asprey interviews Dr.

Dave Asprey interviews Chris Wrench, co-founder of Timeline, about their discovery of Urolithin A, a compound that triggers mitophagy to improve mitochondrial function.

Dave Asprey and Dr.

Host Dave Asprey explains how to stack L-theanine with caffeine to achieve calm, monk-like focus by balancing beta and alpha brainwaves.

Dave Asprey reviews five biohacking stories, including creatine’s benefits for sleep-deprived cognition and microplastics in gum.

This episode features a longevity expert discussing why walking alone is insufficient for health after 50, advocating instead for resistance training to combat muscle loss and bone density decline.

Dave Asprey interviews relationship expert John Gray, who shares biohacking insights on hormones, longevity, and relationships.

Dave Asprey discusses the Fasting Mimicking Diet, a five-day protocol designed to trigger autophagy and gut repair while allowing limited food intake.

Dave Asprey discusses new research linking normal testosterone levels to reduced brain tumor growth and warns of CDC rabies testing delays.

Dave Asprey interviews Philippe Samor von Hatzendorf-Felling about Quantum Upgrade, a remote energy technology claiming to harmonize electromagnetic fields from 5G, Wi-Fi, and EVs.

Dave Asprey discusses a study showing an eight-week protocol of polyphenol-rich foods, supplements, and meditation reduced biological age by over three years.

Dave Asprey explains that brain fog stems from a nervous system stuck in stress mode, not mental weakness.

Dave Asprey discusses biohacking strategies, highlighting a Finnish study linking soil exposure to improved immune diversity and a BMJ study showing exercise variety reduces mortality.

Dave Asprey interviews Brad Pizzoli, founder of 1000 Roads, about Exercise with Oxygen Therapy (EWOT) and red light therapy.

Dave Asprey hosts functional medicine doctor Cynthia Thurlow to discuss optimizing women’s health during perimenopause and menopause.

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Andrew Huberman interviews Caitlin Thompson about Kambo, a poison frog secretion used for healing and performance.

Dave Asprey interviews neuroscientist Dr.

Host Dave Asprey interviews Dr.

Dave Asprey debunks nine common health myths, arguing that saturated fats, intermittent fasting, and high-quality nutrition are superior to low-fat diets and excessive exercise.

Dave Asprey discusses a virologist’s self-administered oncolytic virus cure for cancer, highlighting regulatory delays.

Dave Asprey interviews Justin Gardner about hypochlorous acid, a medical-grade antimicrobial that mimics the body’s natural immune response to accelerate wound healing.

Dave Asprey interviews Jim O’Neill, Acting CDC Director, on shifting US dietary guidelines toward whole foods and saturated fats.

Dave Asprey debunks creatine myths, highlighting its safety and benefits for brain, muscle, and mitochondrial health.