The Human Upgrade: Biohacking for Longevity & Performance The Human Upgrade: Biohacking for Longevity & Performance

The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498

Jul 9, 2026 · 53m

Summary

Dave Asprey hosts Dr. David Perlmutter to discuss neuroinflammation, arguing that microglial shifts drive Alzheimer’s and Parkinson’s rather than amyloid plaques. They critique ineffective beta-amyloid drugs and highlight lifestyle interventions like diet, oral hygiene, and ketones. The conversation also evaluates GLP-1 agonists for reducing brain inflammation and stabilizing neurodegenerative decline, despite potential side effects.

Topics discussed

Sponsor reads: Zenbud and iRestore Introduction of Dr. David Perlmutter Ultra-processed foods and Alzheimer's risk Carbs, gluten, and dietary flexibility Alcohol consumption and brain health Microglia, inflammation, and lifestyle interventions Sponsor reads: Predictive Mind and Peak Critique of amyloid drugs and oral health Dental hygiene and oral microbiome Mitochondria, microglia, and head injuries Ketones, DHA, and CTE in athletes Antibiotics for neuroinflammation Sponsor read: Gatlin GLP-1 drugs for Parkinson's and Alzheimer's 40Hz light therapy and future tech Microglial transplantation and environmental toxins Air pollution, lead, and final thoughts
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