The Human Upgrade: Biohacking for Longevity & Performance The Human Upgrade: Biohacking for Longevity & Performance

I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic : 1513

Aug 4, 2026 · 1h 12m

Summary

Dave Asprey interviews Dr. Vivek Lal about the gut-lung axis and how specific probiotics can enhance respiratory resilience. They discuss how lung microbiome balance reduces inflammation via MMP9 and NLRP3 pathways, potentially mitigating asthma and infection risks. The conversation also covers the dangers of antibiotic overuse, the concept of "air as medicine," and the importance of personal biohacking and self-experimentation for longevity.

Topics discussed

Intro: Breath work, stress, and Zenbud The Missing Piece: Cellular alignment and gut-lung axis Discovering the lung microbiome and low biomass Mechanisms: Inflammation, particle size, and ICU risks Microaspiration and the gut-lung connection Antibiotics, germ-free mice, and epigenetics MMP9, NLRP3, and the future of inhaled probiotics Sponsors: Caldera skincare and Calroy supplements Oysters, MMP9 triggers, and inflammation pathways NLRP3 inflammasome and biohacking regulation Self-experimentation and off-label drug use Telmosartan, microbiome testing, and microbial doping Breath work, Anulom Vilom, and lung resilience Mold, biofilms, and inter-kingdom interactions Resbiotic formulation and clinical trial rigor Target audiences: Smokers, astronauts, and longevity Dead bacteria, MCTs, and food vs supplement claims From lab to market: The inventor's duty and conclusion
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