The Human Upgrade: Biohacking for Longevity & Performance The Human Upgrade: Biohacking for Longevity & Performance

BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin : 1486

Jun 18, 2026 · 1h 1m

Summary

Dave Asprey interviews Dr. Dave Rabin on using psychedelics and nervous system regulation to treat trauma and mental illness. They discuss how ketamine offers a safe entry point, while MDMA and psilocybin provide profound healing by activating safety responses. The episode highlights the Apollo Neuro wearable for vagus nerve stimulation and critiques modern medicine’s failure to address chronic stress and epigenetic trauma.

Topics discussed

Sponsor: iRestore Red Light Therapy for Hair and Skin Sponsor: Viome Personalized Nutrition Testing Introduction: Dr. Dave Smith and Treatment-Resistant Mental Illness Psychedelic Safety, Medical Errors, and Historical Parallels Ketamine as a Safer Alternative to Serotonergic Psychedelics Sponsors: Element Hydration and Gatlin Optimization Managing Anxiety and Serotonin Syndrome Risks The Vagus Nerve, Autonomic Nervous System, and Safety Experiential Learning and Rewiring Fear Responses Modern Overstimulation and Chronic Stress States Neuroelectricity, Trauma, and Epigenetic Changes Sponsor: OneSkin Anti-Aging Skincare MDMA-Assisted Therapy and Epigenetic Repair of Trauma The Role of Therapy, Safety, and Professional Guidelines FDA Delays, Corporate Interference, and Economic Impact Personal Ketamine Experience and Critique of Traditional Therapy Conclusion: Future of Human Potential and Book Promotion
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