The Human Upgrade: Biohacking for Longevity & Performance The Human Upgrade: Biohacking for Longevity & Performance

Brain Fog, Memory Loss, and Alzheimer's Prevention | Dr. Majid Fotuhi : 1482

Jun 11, 2026 · 1h 19m

Summary

Dr. Majid Fautuhi discusses his book *The Invincible Brain*, arguing that cognitive decline is reversible through five pillars: exercise, sleep, nutrition, stress reduction, and brain training. He explains how optimizing these factors shrinks Alzheimer's risk, increases hippocampus size, and improves overall longevity. The episode covers the importance of treating symptoms over lab ranges, the impact of B12 deficiency, and how lifestyle choices can override genetic predispositions like APOE4.

Topics discussed

Intro and Viome Sponsor Segment Guest Intro: Dr. Majid Fautuhi and Brain Health Goals The 5 Pillars of Brain Health and Reversing Cognitive Decline Brain Training, Neuroplasticity, and Creating New Synapses The Hippocampus: Growth Factors and Lifestyle Impacts B12 Deficiency, Lab Ranges, and Functional Medicine Holistic Diagnosis: Connecting Body Systems to Brain Fog Overcoming Brain Fog and the 'I'm Dumb' Narrative Biohacking, Fixed vs. Growth Mindset, and Self-Talk Epigenetics: Controlling Gene Expression Through Lifestyle APOE4 Gene, Alzheimer's Risk, and Success Stories Sponsors: BrainTap, Peak Nandukka, and Pikule Life Understanding Risk Probabilities and Preventing Stroke Lithium in Water, Sugar, and Historical Brain Health VO2 Max, Mitochondria, and Enjoyable Exercise Muscle Mass, Stress Management, and Academic Pressure Psychedelics, GLP-1 Agonists, and Medical Supervision Conclusion: Micro-Decisions, Trust, and Final Advice Outro, Reviews, and Legal Disclaimers
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