Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474
Summary
Host Dave Asprey interviews Dr. Andrew Salzman, a leading biologist, on the gut's role in aging and inflammation. They discuss how leaky gut drives systemic issues and how NAD depletion via CD38 accelerates aging. Salzman explains his company Wonderfeel’s strategy of boosting NAD while inhibiting CD38. He also details creatine’s vital role in shuttling ATP to maintain tight junctions and prevent gut permeability.
Topics discussed
Intro: Gut aging, screen vision, and red light therapy
PARP, DNA repair, and peroxynitrite formation
NAD depletion, CD38, and the bathtub analogy
CD38 knockout mice and Wonderfeel formulation
Gut integrity, tight junctions, and ATP requirements
Creatine phosphate as an energy shuttle system
Energy distribution in neurons and irreversible damage
Microbiome, inflammation, and in vitro testing models
Premature infants, monoclonal antibodies, and IP
FDA criticism, creatine purity, and dosing advice
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