Peptides Explained

Host John Garrett analyzes pinealon, a three-amino acid peptide, distinguishing its promising cellular and animal data from limited human evidence.

Host John Garrett examines Russian peptide bioregulators, such as Epitalon and Thymalin, developed by Vladimir Khavinson.

Host John Garrett debunks the myth of GLP-1 receptor desensitization, explaining that weight plateaus stem from metabolic adaptation rather than damaged receptors.

Host John Garrett examines Cavinson peptide bioregulators, such as Epitalon and Thymalin, exploring their origins in Soviet military research and proposed mechanisms for influencing gene expression.

Host John Garrett debunks the myth that GLP-1 receptor desensitization causes weight loss plateaus on semaglutide, tirzepatide, or retatrutide.

Host John Garrett argues that peptides are tools, not universal health goals, and should only be used for specific, diagnosed medical issues like obesity or persistent injuries.

Host John Garrett examines ARA 290 (sabinatide), an investigational peptide derived from erythropoietin designed to promote tissue repair without stimulating red blood cell production.

Host John Garrett examines Lipo-C, clarifying it is a variable compounded blend of nutrients like carnitine and choline, not a standardized peptide or FDA-approved weight loss drug.

Host John Garrett examines FOXO4-DRI, an experimental senolytic peptide designed to eliminate senescent "zombie" cells by disrupting the FOXO4-p53 interaction.

Host John Garrett examines ATX304, an investigational small molecule dubbed "exercise in a pill," clarifying it is not a peptide but a drug targeting AMPK and mitochondrial energy.

Host John Garrett examines thymocin alpha-1, clarifying it as an immune modulator rather than a booster.

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Host John Garrett reviews his top 11 peptides, categorizing them by evidence level from FDA-approved drugs like terzepatide to experimental compounds like BPC-157.

Host John Garrett examines SLU-PP332, an experimental small molecule marketed as an "exercise mimetic" that activates estrogen-related receptors to boost mitochondrial function.

This episode of Peptides Explained examines NAD Plus, clarifying its biological role in energy production and DNA repair despite not being a peptide.

This episode of Peptides Explained addresses listener requests by analyzing 5-amino-1MQ, clarifying that it is a small molecule NNMT inhibitor rather than a peptide.