The Human Upgrade: Biohacking for Longevity & Performance The Human Upgrade: Biohacking for Longevity & Performance

Inside Kambo: Poison, Purging, and The People Who Swear By It : 1455

Apr 24, 2026 · 44m

Summary

Andrew Huberman interviews Caitlin Thompson about Kambo, a poison frog secretion used for healing and performance. They discuss its peptide pharmacology, traditional Amazonian origins, and modern applications for autoimmune issues and trauma. Thompson shares her personal recovery story, details the intense physical experience, and addresses safety risks like hyponatremia. The episode also covers the lack of scientific research, sustainability concerns, and the potential for synthetic alternatives.

Topics discussed

Sponsors: Viome and iRestore Guest intro: Kaylin's journey with Kambo and autoimmunity Biohacking, resilience, and the cell danger response Historical origins and traditional uses of Kambo The Kambo ceremony: application, effects, and safety Pharmacology, peptides, and recent clinical studies Sponsors: iRestore and Gatlin Scientific challenges and practitioner training standards Legality, sustainability, and synthetic alternatives Indigenous lore, rituals, and spiritual context Sponsor: TrustedHousesitters Safety risks, LD50, and interactions with Ayahuasca Conclusion, resources, and the psychology of pain
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