The a16z Show

a16z General Partner Jennifer Lee discusses H3 Max with Fal co-founders Gorka Mirtsevin and Buwan Tashkaya, highlighting how post-training and…

Host Sophia Du explores whether open source can decentralize AI power at the Open Source AI Summit in San Francisco.

Julie Yu, a16z General Partner and former K Health co-founder, discusses why healthcare is uniquely positioned to benefit from AI by leapfrogging legacy software adoption.

Aaron Levby, co-founder and CEO of Box, joins The a16z Show to argue that open-weight AI drives ecosystem innovation and that the US should support domestic open models to counter Chinese competition.

In this episode, World Labs co-founders Fei-Fei Li, Justin Johnson, and Ben Mildenhall discuss Atlas, a new frontier model built on "new view prediction" to advance spatial intelligence.

In this episode, A16Z general partner Alex Rampell interviews Affirm co-founder Max Levchin about the evolution of payments over the last 25 years.

a16z General Partner Jorge Conde interviews Moderna CEO Stefan Bancel on the company's positive Phase 3 results for its individualized mRNA cancer vaccine in melanoma, developed with Merck.

a16z partner Licia Lee interviews mathematician Daniel Litt on how AI is reshaping mathematical research.

Gavin Baker and David George analyze the AI boom, arguing that current supply constraints and sub-one-year paybacks suggest a positive-sum market…

Jen Kha, Managing Partner at a16z, joins Theo Jaffe and Sophia Du to discuss the firm’s new $1.

Ryan Greenblatt of Redwood Research joins Theo Jaffe to discuss an independent investigation into the OpenAI Hugging Face hacking incident.

a16z partners Ben Horowitz, Ragul Ram, and Martin Casado announce the Machine Age Fund, a new investment vehicle dedicated to the physical infrastructure powering the next era of AI.

a16z partners Martin Casado, Sarah Wang, and Matt Bornstein discuss their investment journey with Cursor, highlighting the team’s contrarian decision…

Jen Ka and Anish Acharya discuss the shift from model competition to the application layer, arguing that AI models are not commodities due to distinct domain specializations and personality traits.

In this episode, hosts Martin Casado and Stephen Sanofsky explore whether AI is shifting computing from an engineering bottleneck to a capital problem.

In this episode, Daisy Wolf and Eva Steinman interview Ng Ziden, co-founder of Protege, about the critical need for independent AI evaluations in healthcare.

Martin Casado of a16z joins Theo Jaffe and Sophia Dew to analyze recent $60 billion acquisitions of Cursor and OpenRouter, arguing that AI has…

Joel De La Garza interviews Aaron Zolman, Microsoft’s Deputy CISO, at Black Hat about securing AI agents that can access data, write code, and act autonomously.

In this episode, Elena Berger interviews a16z partners Angela Strange and Gabriel Vasquez about the rise of "borderless founders"—international…

A16Z’s David George interviews WhatNot co-founder Grant LaFontaine on the rise of live commerce, which accounts for 30-40% of Asian sales but remains single-digit in the U.

Joel De La Garza interviews Nick Warner of NEO and Max Pollard of Kotool to discuss how AI agents are breaking traditional cybersecurity models.

In this episode, a16z’s David George interviews Stripe’s Will Gabrick on how AI is transforming software development and commerce.

Travis Kalanick joins Ben Horowitz to discuss his new venture, Adams, which aims to automate multi-trillion-dollar industries like food, mining, and transport through industrial AI.

Elena Berger, Joe Schmidt, and Andy McCall discuss two competing go-to-market strategies for enterprise AI startups: the "lighthouse" approach, which…

Anish Acharya interviews Y Combinator CEO Gary Tan on how AI empowers solo founders to operate like large teams.

A16Z’s Joel De La Garza interviews Datadog CISO Emilio Escobar on securing AI coding agents.

Angela Strange and Gabriel Vasquez interview Kavak’s Chief Product and AI Officer, Alejandro Ayala, about rebuilding the used-car marketplace as an AI-native company.

Joel De La Garza interviews Dylan Airy and Feras Abukadije on how AI models are increasingly exploiting software supply chains and stolen credentials.

Elena Berger and Matt Bornstein interview Simon Mo, CEO of InfraAct and lead maintainer of the VLLM inference engine, on the rise of open-weight AI models.

This episode features Will O'Brien of Ulysses, who discusses building autonomous underwater robots for conservation, infrastructure, and defense, while also exploring the resurgence of seasteading.

Theo Jaffe interviews OpenAI Chief Futurist Joshua Akiyama on the normalization of advanced AI and its cyber implications.

MTS hosts Sophia Du and Sophia Puccini interview cyber ethnographer Ruby J.

Host Robert Hackett interviews Mark Andreessen and Chris Dixon on the critical need for the Clarity Act to regulate crypto.

Sarah Wang and Kimberly Tan interview Decagon co-founders Jesse Zhang and Ashwin Srinivas about shifting 90% of their AI stack to open-source models for better latency and control.

Justine Moore joins the a16z Show to discuss the rise of AI-native entertainment, particularly the explosion of AI microdramas.