Radiolab Radiolab

The Sweetest Thing

Sep 18, 2026 · 31m

Summary

Reporter Latif Nasser explores the science of sweetness, starting with a quest to find the sweetest substance on Earth. He interviews experts who explain that while artificial sweeteners like lugdunum are more potent, natural sugar often provides the highest perceived intensity. The episode also covers how smell, color, and sound can enhance sweetness perception, and how neuroscientists use lasers to stimulate sweet receptors in mice. Finally, Nasser discovers that a sugar found in raspberries exists in deep space, suggesting the universe may contain its own version of sweetness.

Topics discussed

Sponsors and show introduction The origin of the quest: kids ask what is the sweetest thing Defining the goal: potency vs. intensity of sweetness The top 5 sweetest substances: from honey to Lugdum Tasting experiment: why artificial sweeteners taste bad The science of perception: why sugar is the most intense Evolutionary roots: why humans crave sugar and sweetness Sponsors and introduction of guest Dan Pashman How smell and vision enhance the perception of sweetness Experiment: using color and sound to boost sweetness Neuroscience: mapping the sweet signal in the brain Optogenetics: using lasers to create artificial sweetness Space raspberries: finding sugar in interstellar dust Conclusion and credits Latif Nasser's note on vocal cord injury Staff credits and final sponsors
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