Radiolab Radiolab

Patient Zero

Aug 21, 2026 · 51m

Summary

This Radiolab episode explores the concept of "Patient Zero" through three distinct stories. It begins with Typhoid Mary, an asymptomatic carrier quarantined for spreading disease, then debunks the myth of Gaëtan Dugas as the origin of the AIDS epidemic, tracing HIV instead to a chimpanzee spillover in Cameroon around 1908. Finally, it investigates the true invention of the high-five, crediting gay baseball player Glenn Burke over a later popularized narrative.

Topics discussed

Intro: Live taping and disease outbreaks Typhoid Mary: The hunt for Patient Zero Mary Mallon's quarantine on North Brother Island Ad break: Capital One AIDS Epidemic: Gaetan Dugas as Patient Zero Tracing HIV origins to 1908 Congo SIV in chimps and the spillover event Ad break: Capital One The myth of the high five inventor Glenn Burke: The real origin of the high five Debunking the myth and concluding thoughts Outro and staff credits
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