Huberman Lab Huberman Lab

Essentials: Manage Stress & Build Resilience | Dr. Elissa Epel

Oct 8, 2026 · 34m

Summary

Dr. Alyssa Eppel explains that stress is a natural response, but chronic rumination harms health by depleting mitochondrial energy. She distinguishes between a "threat" response and a "challenge" response, noting that reframing stressors as opportunities builds resilience. For uncontrollable situations, she recommends radical acceptance to stop "pulling on a brick wall." Finally, she highlights that maintaining positive emotions and a coherent life narrative at night protects against accelerated aging.

Topics discussed

Introduction and the nature of stress: acute vs. chronic Managing overthinking and recognizing physical stress signals Three strategies for stress: awareness, body, and environment Forms of stress and the energy cost of vigilance Sponsor: 8Sleep smart mattress covers Optimal aging and the benefits of moderate challenge Threat vs. challenge responses and physiological differences Building stress resilience through mindset and reframing Sponsor: AG1 Pro nutritional supplement Mitochondrial health, mood, and chronic stress impact Radical acceptance and the 'brick wall' metaphor Tolerating uncertainty and adopting a receptive posture Sponsor: Roka Red Lens glasses for sleep Balancing agency ('muscling') with release ('letting go') The power of narrative and finding purpose in stress Closing remarks and gratitude
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