10% Happier with Dan Harris 10% Happier with Dan Harris

The Science of Habit Change, Why GLP-1s are Disrupting It, and How To Use It To Have Better Conversations | Charles Duhigg

Aug 31, 2026 · 1h 8m

Summary

Dan Harris and Charles Duhigg explore the neuroscience of habit formation, using the "cue-routine-reward" loop to reprogram behaviors like sleep and exercise. They discuss how "keystone habits" shift self-identity to trigger cascading positive changes. The conversation also examines how GLP-1 medications create a temporary "habit window" by silencing cravings, allowing users to build lasting routines before the medication's effects fade.

Topics discussed

Introduction and guest welcome The neuroscience of habit formation Memory vs. habits and the basal ganglia The habit loop: cue, routine, and reward Analyzing Dan Harris's late-night habit Applying the golden rule to change a habit The golden rule of habit change Sponsor: 10% Happier app and reset theme Sponsor: OSEA skincare Human agency vs. Pavlovian conditioning The role of willpower in habit change Keystone habits and self-identity Overcoming fear and building new identities GLP-1s and the 'habit window' for change Sponsor: FitNexa Somni Pods Sponsor: Lincoln Tech GLP-1s, cravings, and personal experience GLP-1s vs. intuitive eating and diet culture Side effects, cost, and discontinuation rates Sponsors: Wayfair and Bombas Applying habit loops to communication skills What is good: recent books and documentaries Book recommendations and show credits
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