The Science of Habit Change, Why GLP-1s are Disrupting It, and How To Use It To Have Better Conversations | Charles Duhigg
Aug 31, 2026 · 1h 8m
Summary
Dan Harris and Charles Duhigg explore the neuroscience of habit formation, using the "cue-routine-reward" loop to reprogram behaviors like sleep and exercise. They discuss how "keystone habits" shift self-identity to trigger cascading positive changes. The conversation also examines how GLP-1 medications create a temporary "habit window" by silencing cravings, allowing users to build lasting routines before the medication's effects fade.
Topics discussed
Introduction and guest welcome
The neuroscience of habit formation
Memory vs. habits and the basal ganglia
The habit loop: cue, routine, and reward
Analyzing Dan Harris's late-night habit
Applying the golden rule to change a habit
The golden rule of habit change
Sponsor: 10% Happier app and reset theme
Sponsor: OSEA skincare
Human agency vs. Pavlovian conditioning
The role of willpower in habit change
Keystone habits and self-identity
Overcoming fear and building new identities
GLP-1s and the 'habit window' for change
Sponsor: FitNexa Somni Pods
Sponsor: Lincoln Tech
GLP-1s, cravings, and personal experience
GLP-1s vs. intuitive eating and diet culture
Side effects, cost, and discontinuation rates
Sponsors: Wayfair and Bombas
Applying habit loops to communication skills
What is good: recent books and documentaries
Book recommendations and show credits
Listen ad-free on Castria