You Are Not So Smart You Are Not So Smart

346 - No Nocebo Effect - Helen Pilcher

Aug 17, 2026 · 59m

Summary

Host David McRaney interviews neuroscientist Helen Pilcher about her book, "This Book May Cause Side Effects," which explores the nocebo effect. Pilcher discusses how negative expectations and beliefs can physically manifest symptoms, citing examples like anticipatory nausea in chemotherapy patients and historical cases of voodoo death. She emphasizes that while thoughts influence health, they cannot cure diseases like cancer, urging listeners to maintain trust in evidence-based medical treatments rather than relying on positive thinking alone.

Topics discussed

Lowe's Labor Day Savings Ad Introduction: Helen Pilcher's Cancer Diagnosis and Hesitation Early Research on the Nocebo Effect and Symptom Creation Pilcher's Decision to Research Instead of Google Her Diagnosis The Placebo Effect: Rituals, Expectations, and Clinical Trials Sponsor Ads: Lowe's, Ashley, School of Thought, and Kitted Defining Nocebo vs. Placebo and the Myth of Voodoo Death Case Study: The Man Who Died of a Misdiagnosed Cancer Nocebo Side Effects in Clinical Trials and Real Life Conditioned Nausea in Chemotherapy Patients Mesmer's Head and the Danger of Anti-Science Extremes The Importance of Conventional Medical Treatment The Beer Box Experiment and Alcohol-Free Hangovers Functional Neurological Disorder: The Woman Who Couldn't Walk Treating FND by Challenging Brain Predictions Outro, Show Notes, and Social Media Links
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