What Now? with Trevor Noah What Now? with Trevor Noah

Emily McDonald: Can You Rewire Your Brain?

Mar 19, 2026

Summary

Trevor Noah and Eugene Lee speak with neuroscience PhD Em about rewiring the brain to break addictions like vaping by changing dopamine associations. They explore how habits form through cue-response loops and why cold turkey often fails due to stress-induced impulse control loss. Em bridges scientific concepts like neuroplasticity with spiritual practices, explaining how visualization and intuition align with brain function. The discussion also covers the history of science dismissing spiritual ideas and how to critically evaluate research studies.

Topics discussed

Intro: Intergenerational living and sponsor reads Guest background: Pre-med to neuroscience research Nicotine addiction and the mechanics of craving Dopamine, salience, and habit formation Relapse triggers and the role of stress Neuroscience of meditation and binaural beats Sponsors: Apple Card, HelloFresh, and Carhartt Spirituality, religion, and past life regression Critique of pop psychology and study validity Epigenetics and gene expression Intergenerational care models and sponsors Neuroplasticity, sensory deprivation, and ADHD Stress responses and the 'deer in headlights' effect Visualization techniques and mental rehearsal Reprogramming the brain for relationships Self-talk, journaling, and affirmations Psychedelics, ayahuasca, and addiction recovery Hypnosis, identity change, and societal structures Conclusion: Changing internal reality and final sponsors
Listen ad-free on Castria