Host Dr. Scott Barry Kaufman interviews Dr. Alia Crum on how subjective mindsets alter objective reality through physiological and behavioral mechanisms. They discuss her research on the placebo effect, including the "Mind Over Milkshakes" study, which showed beliefs about food impact hunger hormones. The conversation covers rethinking stress as enhancing rather than debilitating and how perceived genetic risk perceptions influencing cardiovascular efficiency, demonstrating that changing mindsets can improve health outcomes in areas like cancer care and performance.