FDA Commissioner Dr. Marty McCary resigned amid a leadership shakeup driven by President Trump’s frustration over stalled vaping approvals. McCary’s tenure faced criticism from the pharmaceutical industry and GOP allies for drug rejections and slow action on abortion pill reviews. The vaping controversy, specifically the rejection of flavored e-cigarettes, accelerated his ouster as Trump sought to fulfill campaign promises to the vaping industry. Acting commissioner Kyle Diamantis now leads the agency amid a policy shift allowing unapproved nicotine products to market.