Hosts Robert Lamb and Joe McCormick explore the psychological phenomenon of "prairie madness," analyzing how 19th-century homesteaders reacted to the vast, treeless landscape through literature and historical accounts. They discuss potential causes like isolation, sensory deprivation, and wind sounds, noting the concept was likely a cultural construct rather than a medical reality. The episode concludes with an examination of Mima Mounds, mysterious geological formations whose origins remain debated, with theories ranging from glacial melt patterns to seismic activity.