The Nocebo Effect: Placebo’s Evil Twin & Weird Facts You Never Knew
Sep 7, 2026 · 48m
Summary
Host Mike Carruthers explores the nocebo effect with science writer Helen Pilcher, revealing how negative expectations can trigger real physical symptoms. The episode also features language expert Jess Zafaris, who shares fascinating etymologies for words like "sideburns" and "dude," as well as the history of generic trademarks such as "Kleenex" and "Bubble Wrap." Additionally, the show covers the surprising origins of Chopin’s heart, the power of walking for creativity, and the psychological phenomenon of the spotlight effect.
Topics discussed
Sponsored segment: Dell XPS laptop
Episode preview: medical student syndrome and word origins
Sponsored segment: Wayfair home goods
The creative benefits of walking
Introduction to the nocebo effect
Interview with Helen Pilcher: nocebo vs placebo
How expectations influence drug side effects
Nocebo effects in vaccines and chemotherapy
Subconscious conditioning and illness narratives
Suggestibility and medical student syndrome
Sponsored segment: Quince clothing
Sponsored segment: Monarch finance app
Managing chronic pain via attention to variability
Nocebo impact on behavior and treatment adherence
The story of Sam Schuman and misdiagnosis
Takeaways and conclusion of nocebo segment
Sponsored segments: Progressive and Shopify
Interview with Jess Zafaris: word origins
Etymology of 'mesmerize', 'boycott', and 'dude'
The true meaning of 'factoid'
Surprising histories of inventions
The journey of Chopin's heart
Genericized trademarks: Kleenex, Velcro, Moxie
Banned songs and their histories
The story of 'antidisestablishmentarianism'
Conclusion of word history segment
The spotlight effect and social anxiety
Sponsored segment: Uber Eats
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