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The Nocebo Effect: Placebo’s Evil Twin & Weird Facts You Never Knew

Sep 7, 2026 · 48m

Summary

Host Mike Carruthers explores the nocebo effect with science writer Helen Pilcher, revealing how negative expectations can trigger real physical symptoms. The episode also features language expert Jess Zafaris, who shares fascinating etymologies for words like "sideburns" and "dude," as well as the history of generic trademarks such as "Kleenex" and "Bubble Wrap." Additionally, the show covers the surprising origins of Chopin’s heart, the power of walking for creativity, and the psychological phenomenon of the spotlight effect.

Topics discussed

Sponsored segment: Dell XPS laptop Episode preview: medical student syndrome and word origins Sponsored segment: Wayfair home goods The creative benefits of walking Introduction to the nocebo effect Interview with Helen Pilcher: nocebo vs placebo How expectations influence drug side effects Nocebo effects in vaccines and chemotherapy Subconscious conditioning and illness narratives Suggestibility and medical student syndrome Sponsored segment: Quince clothing Sponsored segment: Monarch finance app Managing chronic pain via attention to variability Nocebo impact on behavior and treatment adherence The story of Sam Schuman and misdiagnosis Takeaways and conclusion of nocebo segment Sponsored segments: Progressive and Shopify Interview with Jess Zafaris: word origins Etymology of 'mesmerize', 'boycott', and 'dude' The true meaning of 'factoid' Surprising histories of inventions The journey of Chopin's heart Genericized trademarks: Kleenex, Velcro, Moxie Banned songs and their histories The story of 'antidisestablishmentarianism' Conclusion of word history segment The spotlight effect and social anxiety Sponsored segment: Uber Eats
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