Short Wave Short Wave

How your metabolism could alter your mental health

Aug 26, 2026 · 12m

Summary

NPR’s Shortwave explores metabolic psychiatry with Dr. Shabani Sethi, who links metabolism to schizophrenia, depression, and bipolar disorder. She explains how cerebral glucose hypometabolism affects brain health and discusses ketogenic metabolic therapy as a monitored medical intervention. The episode highlights research showing diet can improve both metabolic and psychiatric markers, urging a holistic view of mental health.

Topics discussed

Introduction to metabolic psychiatry and Shabani Sethi Sponsors: Grainger, Amazon Health, SNHU Schizophrenia and cerebral glucose hypometabolism Metabolic links to bipolar disorder and depression Ketogenic metabolic therapy (KMT) explained Brain benefits of ketosis and clinical trials Addressing long-term risks and pilot study results Balancing hope with scientific honesty Outro, credits, and sponsors
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