Short Wave Short Wave

Should we reengineer the world's deadliest animal?

May 27, 2026 · 11m

Summary

NPR’s Short Wave interviews Ben Bradford about using CRISPR gene drives to eradicate malaria-carrying mosquitoes. The discussion explores the potential to save millions of lives by engineering mosquitoes that only produce males, effectively halting disease transmission. However, experts warn of significant ecological risks and the danger of unintended consequences if these modified insects escape containment. The episode weighs the moral imperative to stop deadly diseases against the potential for irreversible environmental damage.

Topics discussed

Intro: Mosquitoes, gene editing, and the 'Are We Doomed?' podcast Sponsors: Schwab, Edward Jones, and Integrative Therapeutics How CRISPR gene drives could eradicate malaria-carrying mosquitoes Ecological risks and the 'sabbatical' strategy for mosquitoes The challenge of testing: Creating a 'Mosquito Jurassic Park' Historical lesson: The rabbit plague and biological weapon smuggling Risks of accidental release and global ecological domino effects The debate: Gene drives vs. public backlash and safety concerns Ethical dilemmas and the pressure to solve mosquito-borne diseases Outro: Promoting 'Are We Doomed?' and NPR app credits Trailers: KERA's Think, Tiny Desk Tour, and Up First headlines
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