The mystery that led this family to get their stomachs removed
Summary
This episode explores how Māori families, led by nurse Maybel McLeod, helped identify the CDH1 gene mutation linked to diffuse gastric cancer. Host Emily Kwong interviews Sarah Zhang about the discovery and the difficult choice faced by those at risk, like Karen Perangata, who underwent prophylactic total gastrectomy. The discussion covers the surgery’s physical and psychological impacts, including dietary changes and increased alcohol use disorder risk, highlighting the trade-offs of preventative medicine.
Topics discussed
Intro: Maori families, stomach cancer, and the choice of surgery
Sponsors: Schwab, Allianz Travel, Capella University, NPR App
The CDH1 gene mutation and Maybel McLeod's discovery
Community-led genetic research and sample collection
The gastrectomy procedure and immediate dietary changes
Long-term life adjustments: socializing, weight, and B12
Unexpected link between stomach removal and alcoholism
Medical ethics: weighing cancer risk against quality of life
Karen's story: reconnection with family and living without a stomach
Outro, credits, and final sponsor messages
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