Short Wave Short Wave

Could this anti-aging dog pill lead to one for you too?

Jul 7, 2026 · 11m

Summary

Ross Anderson discusses Loyal’s new pill designed to extend dogs' lives by restoring insulin sensitivity and reducing inflammation. The drug, which targets metabolic aging, aims to improve healthspan and may eventually inform human longevity research. With conditional FDA approval pending, the beef-flavored pill could be available next year for dogs over ten. Anderson plans to use it for his dog, Forrest, once final trials confirm its efficacy.

Topics discussed

Intro: Loyal's pill to extend dog lifespans and founder Celine Holowa History of life extension: Cynthia Kenyon and C. elegans worms Metabolism and aging: Caloric restriction studies in dogs How the pill works: Restoring insulin sensitivity to reduce inflammation FDA approval status: Efficacy, safety, and manufacturing hurdles Why dogs first? Pill compliance and taste testing with beef flavor Personal take: Ross Anderson's dog Forrest and future plans Outro and blooper: Verifying dog ages via Facebook posts Sponsors: Leaf Filter and KERA's THINK program
Listen ad-free on Castria