Science Friday Science Friday

What is ibogaine, and why is it in the news?

Apr 29, 2026 · 19m

Summary

This episode examines the renewed political and scientific interest in ibogaine, a psychedelic drug with potential for treating opioid addiction and PTSD. Host Flora Lichtman speaks with neuroscientist Dr. Deborah Mash and journalist Jane Hood about recent FDA fast-tracking efforts supported by President Trump and Joe Rogan. The discussion covers ibogaine’s history, its cardiac risks, and the therapeutic promise of its metabolite, noribogaine, while contrasting it with other psychedelics like psilocybin.

Topics discussed

Sponsors: Progressive Insurance and Alienware Trump administration fast-tracks psychedelic research The recent resurgence of ibogaine interest Dr. Mash's history with ibogaine research Barriers to mainstream ibogaine adoption Ibogaine's heart risks and pharmacokinetics Noribogaine: A safer metabolite without the trip Listener story: Craig's ibogaine experience Describing the ibogaine therapeutic journey Ibogaine vs. psilocybin and cultural factors Conclusion and call for evidence-based access
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