Science Friday Science Friday

How does the gut-brain connection work?

Jul 8, 2026 · 36m

Summary

Host Flora Lichtman interviews Dr. Emeran Mayer and Dr. Trisha Pasricha about the gut-brain connection. They discuss the enteric nervous system, the gut’s role in Parkinson’s disease, and the impact of GLP-1 drugs. The experts also critique the commercialization of microbiome testing and emphasize the importance of diet over isolated supplements for maintaining health.

Topics discussed

Intro: Science Friday and Aspen Ideas Health Defining the gut and the rise of gut health culture IBS, misinformation, and the role of influencers The enteric nervous system: The gut as a second brain Bidirectional communication via the vagus nerve Parkinson's disease and the gut-brain connection GLP-1 drugs and their systemic effects Microbiome diversity and the limits of testing Probiotics, diet, and holistic mental health
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