Sawbones: Artificial Sweetener
Sep 22, 2026 · 36m
Summary
Hosts Justin and Sydney McElroy discuss a recent study linking high blood levels of xylitol to increased cardiovascular risk, emphasizing that correlation does not imply causation. They explore the history of artificial sweeteners, from saccharin’s accidental discovery to cyclamate’s ban and aspartame’s ongoing safety debates, noting that many were invented during wartime sugar rationing. The episode highlights the importance of moderation, warning that the "health halo" of sugar-free products can encourage excessive consumption. Finally, they stress the need for robust regulatory oversight…
Topics discussed
Intro and medical disclaimer
Hosts discuss seasonal rasp and football
European Society of Cardiology congress context
What is xylitol and its common uses
New study linking xylitol to heart risk
Correlation vs causation and dose dependence
History of Certs and trans fat ban
Origins of xylitol and sugar substitutes
Sponsor: Quince clothing
Sponsor: Squarespace
Promos: E Pluribus Motto and Comfort Creatures
Saccharin: discovery, ban, and cancer fears
Cyclamate: discovery and bladder cancer ban
Aspartame: discovery, PKU, and safety
Sucralose (Splenda) and heat stability
Newer sweeteners: Neotame, Advantame, Stevia
Moderation and the 'healthy' label trap
Importance of FDA regulation and safety
Outro and credits
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