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Sawbones: Artificial Sweetener

Sep 22, 2026 · 36m

Summary

Hosts Justin and Sydney McElroy discuss a recent study linking high blood levels of xylitol to increased cardiovascular risk, emphasizing that correlation does not imply causation. They explore the history of artificial sweeteners, from saccharin’s accidental discovery to cyclamate’s ban and aspartame’s ongoing safety debates, noting that many were invented during wartime sugar rationing. The episode highlights the importance of moderation, warning that the "health halo" of sugar-free products can encourage excessive consumption. Finally, they stress the need for robust regulatory oversight…

Topics discussed

Intro and medical disclaimer Hosts discuss seasonal rasp and football European Society of Cardiology congress context What is xylitol and its common uses New study linking xylitol to heart risk Correlation vs causation and dose dependence History of Certs and trans fat ban Origins of xylitol and sugar substitutes Sponsor: Quince clothing Sponsor: Squarespace Promos: E Pluribus Motto and Comfort Creatures Saccharin: discovery, ban, and cancer fears Cyclamate: discovery and bladder cancer ban Aspartame: discovery, PKU, and safety Sucralose (Splenda) and heat stability Newer sweeteners: Neotame, Advantame, Stevia Moderation and the 'healthy' label trap Importance of FDA regulation and safety Outro and credits
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