Relentless Health Value Relentless Health Value

Generic Compliance Ratios, Pass-Through Contracts, and Other Pharmacy Plumbing, With Mark Cuban and Cora Opsahl

Aug 26, 2026 · 20m

Summary

Host Stacey Hensley interviews Mark Cuban and Cora Opsal to expose pharmacy supply chain inefficiencies. They discuss how generic compliance ratios and opaque PBM pricing models, like inflated AWP discounts, drive up costs for patients and employers. The episode highlights the disparity between cash prices and insurance reimbursements, using imatinib as a key example. Listeners learn how to negotiate pass-through contracts and demand transparency to protect plan assets.

Topics discussed

Introduction: Mark Cuban, Cora Opsal, and the mystery of pharmacy margins Sponsor acknowledgments and show credits Wholesaler consolidation and the Imatinib pricing example Discount theater: Why AWP and WAC are misleading reference prices Generic compliance ratios and how they trap pharmacies High deductibles, specialty tiers, and patient out-of-pocket costs Employer RFPs and the disconnect between reimbursement and billing Pass-through PBM contracts and the black box of math The failure of consultants and the limitations of PBM audits Negotiating for data transparency and leveraging Cost Plus Drugs Mark Cuban's endorsement of the Relentless Health Value podcast
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