Let’s Kill Sh*t: Axios CEO on simplifying your work-life in the AI era
Sep 15, 2026 · 32m
Summary
Jim Van Der Heide, CEO of Axios and co-author of "Simplify," discusses the 2024 midterm elections and the accelerating pace of AI-driven change. He introduces a "confront, delete, amplify" framework to combat cognitive fatigue and reclaim wasted time, arguing that AI currently creates more noise rather than efficiency. Van Der Heide also shares how he uses custom AI agents for personal healthcare and explains Axios’s strategy for expanding local news through technology.
Topics discussed
Promo: Masters of Scale Summit and Podcast
Intro: Jim VandeHei and the book 'Simplify'
Midterm elections and economic impact on business
Why data centers have become politically toxic
Post-processable velocity and the speed of AI change
The 'Messy Middle' of AI adoption and cognitive fatigue
Framework: Confronting habits and deleting waste
Amplifying priorities and killing the Axios app
The value of time and reducing meeting bloat
Managing decision fatigue and personal automation
Sponsor: Engine business travel solutions
Revitalizing local news with AI cost efficiency
AI as a force multiplier for human jobs
Axios-OpenAI deal and avoiding platform dependency
Building custom AI agents for healthcare
Redesigning personal life and social boundaries
Three actionable tips for business leaders
Outro: Prioritizing human energy in the AI era
Sponsor: Engine travel and show credits
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