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Let’s Kill Sh*t: Axios CEO on simplifying your work-life in the AI era

Sep 15, 2026 · 32m

Summary

Jim Van Der Heide, CEO of Axios and co-author of "Simplify," discusses the 2024 midterm elections and the accelerating pace of AI-driven change. He introduces a "confront, delete, amplify" framework to combat cognitive fatigue and reclaim wasted time, arguing that AI currently creates more noise rather than efficiency. Van Der Heide also shares how he uses custom AI agents for personal healthcare and explains Axios’s strategy for expanding local news through technology.

Topics discussed

Promo: Masters of Scale Summit and Podcast Intro: Jim VandeHei and the book 'Simplify' Midterm elections and economic impact on business Why data centers have become politically toxic Post-processable velocity and the speed of AI change The 'Messy Middle' of AI adoption and cognitive fatigue Framework: Confronting habits and deleting waste Amplifying priorities and killing the Axios app The value of time and reducing meeting bloat Managing decision fatigue and personal automation Sponsor: Engine business travel solutions Revitalizing local news with AI cost efficiency AI as a force multiplier for human jobs Axios-OpenAI deal and avoiding platform dependency Building custom AI agents for healthcare Redesigning personal life and social boundaries Three actionable tips for business leaders Outro: Prioritizing human energy in the AI era Sponsor: Engine travel and show credits
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