NEJM This Week — August 13, 2026
Summary
This NEJM This Week episode covers trials on secukinumab for polymyalgia rheumatica, base editing for hypercholesterolemia, selpercatinib for lung cancer, and talquetamab for myeloma. It also reviews tobacco cessation strategies, a methanol poisoning case, and gene editing for rare metabolic diseases. Perspectives address HIV care, pay-for-performance ethics, and physician resilience.
Topics discussed
Introduction and episode overview
Secukinumab trial for polymyalgia rheumatica
Base editing therapy for hypercholesterolemia
Selpercatinib for early-stage lung cancer
Talquetamab for relapsed multiple myeloma
Tobacco cessation strategies in low-income countries
Case record: Methanol toxicity diagnosis
Gene editing for rare metabolic diseases
Critique of pay-for-performance in healthcare
Long-acting ART for advanced HIV disease
Physician ethics and strategic compromise
Perspective: Resilience and running with ALS
Images in clinical medicine: Tumors and infection
Conclusion and contact information
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