NEJM This Week — July 23, 2026
Summary
This episode covers major advances in pancreatic and bladder cancer treatments, including Diraxon RASIB and Enfortumab-vidotin-pembrolizumab. It also discusses a failed gonorrhea vaccine trial, a new therapy for adolescent hypertrophic cardiomyopathy, and a review of HIV antiretroviral therapy. Additional topics include a case of Bartonella neuroretinitis, perspectives on vaccine evidence, hepatitis C elimination in prisons, social media drug promotion, and the intersection of love and loss in medicine.
Topics discussed
Introduction and episode overview
Diraxon RASIB for metastatic pancreatic cancer
Enfortumab-vedotin-pembrolizumab for bladder cancer
Meningococcal B vaccine for gonorrhea prevention
Mavacamten for adolescent hypertrophic cardiomyopathy
Review of antiretroviral therapy for HIV
Case record: Vision loss and Bartonella neuroretinitis
Perspective: Vaccine evidence from trials and observational data
Perspective: Hepatitis C elimination in prisons and jails
Perspective: Regulating drug promotion on social media
Perspective: Love and loss in medicine
Images in clinical medicine and closing remarks
Listen ad-free on Castria