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OpenAI’s Big Reset + A.I. in the Doctor’s Office + Talkie, a pre-1930s LLM

May 1, 2026

Summary

Hosts Kevin Roose and Casey Newton analyze OpenAI’s strategic reset, including new Microsoft and Amazon deals, scaled-back infrastructure plans, and the ongoing Elon Musk lawsuit. They discuss the company’s pivot to ad-supported subscriptions and internal growth tensions. Dr. Adam Rodman then joins to examine AI’s rapid adoption in medicine, covering tools like AI scribes and decision support, while advising on safe patient use of health chatbots.

Topics discussed

Intro: Audi Q3 ad and Codex goblin guardrails OpenAI-Microsoft deal changes and Amazon investment AI infrastructure spending and Meta's Stargate project OpenAI's business model shift to consumer subscriptions Elon Musk's lawsuit against OpenAI and trial details New York Times subscription ad break AI adoption in medicine: Scribes and decision support Patient use of AI and risks of autonomous prescribing AI in drug discovery and medical education concerns Intro to Taki: An AI model trained on pre-1930 data Taki's forecasting abilities and historical knowledge Taki's personality, safety filters, and scientific potential
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