OpenAI’s Big Reset + A.I. in the Doctor’s Office + Talkie, a pre-1930s LLM
May 1, 2026
Summary
Hosts Kevin Roose and Casey Newton analyze OpenAI’s strategic reset, including new Microsoft and Amazon deals, scaled-back infrastructure plans, and the ongoing Elon Musk lawsuit. They discuss the company’s pivot to ad-supported subscriptions and internal growth tensions. Dr. Adam Rodman then joins to examine AI’s rapid adoption in medicine, covering tools like AI scribes and decision support, while advising on safe patient use of health chatbots.
Topics discussed
Intro: Audi Q3 ad and Codex goblin guardrails
OpenAI-Microsoft deal changes and Amazon investment
AI infrastructure spending and Meta's Stargate project
OpenAI's business model shift to consumer subscriptions
Elon Musk's lawsuit against OpenAI and trial details
New York Times subscription ad break
AI adoption in medicine: Scribes and decision support
Patient use of AI and risks of autonomous prescribing
AI in drug discovery and medical education concerns
Intro to Taki: An AI model trained on pre-1930 data
Taki's forecasting abilities and historical knowledge
Taki's personality, safety filters, and scientific potential
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