Extra: CMLase - The Enzyme That Could Reverse Ageing
Summary
Dr. Aaron Cravens of Revel Pharmaceuticals discusses the discovery of CMase, an enzyme that reverses chemical aging in structural proteins like collagen. By targeting "rust" caused by glycation and oxygen, the treatment reduces inflammation and tissue stiffness in human samples. Cravens explains how AI and microbial screening identified this enzyme, which can reverse decades of protein aging in vitro. While promising for eye, kidney, and cardiovascular health, clinical trials are expected to begin in approximately two years.
Topics discussed
QVC shopping promotion
Introduction to anti-aging research and CMase
The car analogy for biological aging
Defining structural rust in non-cellular tissues
Inflammation and tissue stiffness caused by rust
The surprise of reversing irreversible aging
Searching nature for de-rusting enzymes
Identifying the initial CMase candidate
AI-driven optimization of the enzyme
Results: Reversing protein aging in human tissue
Limitations and the need for multiple interventions
Potential clinical impacts on eyes and kidneys
Future timeline for human trials
Closing remarks and credits
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