Episode 147: Multiple Myeloma Part 2
Summary
In this episode, hosts Brit Long and Manny Singh continue their multiple myeloma series by detailing infection risks, musculoskeletal complications, and neurologic emergencies. They highlight the high mortality from sepsis, the prevalence of pathologic fractures, and the critical need for MRI in suspected spinal cord compression. The discussion also covers cardiac toxicity, venous thromboembolism, and endocrine issues related to myeloma therapies.
Topics discussed
Introduction and recap of Part 1
Infection risks, common pathogens, and statistics
Infection management and the LUCASS mnemonic
Musculoskeletal issues: bone pain and osteolytic disease
Fractures: pathologic vs insufficiency and imaging
Spinal cord compression and cauda equina syndrome
Nerve root compression and peripheral neuropathy
Neuropathy management and autonomic nervous system
CNS involvement: intracranial myeloma and orbits
Leptomeningeal myelomatosis and encephalopathy
Cardiac complications and thrombotic risks
VTE prophylaxis and endocrine disorders
Episode summary and key takeaways
Listen ad-free on Castria