Episode 147: Multiple Myeloma Part 1
Summary
Hosts Britt Long and Manny Singh discuss multiple myeloma, focusing on its presentation in the emergency department. They review the CRAB mnemonic for diagnosis and detail management for common complications, including anemia, hyperviscosity syndrome, and renal failure. The episode provides specific treatment algorithms for hypercalcemia, covering fluid resuscitation, bisphosphonates, and denizumab.
Topics discussed
Introduction and overview of multiple myeloma
Epidemiology, demographics, and prognosis
Initial presentation and CRAB mnemonic
Identifying undiagnosed myeloma in the ED
Hematologic complications: Anemia management
Hyperviscosity syndrome and coagulopathy
Renal complications and management
Hypercalcemia: Diagnosis and severity levels
Hypercalcemia: Pharmacologic treatment options
Electrolyte management and hemodialysis indications
Conclusion and preview of next episode
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