GLP-1s: Your questions answered
Oct 22, 2026 · 17m
Summary
Professor Donald O'Shea, an obesity specialist, joins *Drive Time* to answer listener questions regarding the use, side effects, and long-term management of GLP-1 medications in Ireland. He addresses concerns about access through the Drugs Payment Scheme, the necessity of lifelong treatment for chronic obesity, and the importance of maintaining muscle mass to prevent frailty. The discussion also covers practical advice on injection sites, dosing schedules, and managing potential complications like pancreatitis.
Topics discussed
Introduction and listener questions
Listener case: Severe obesity and cost barriers
Access to Saxenda and future HSE decisions
Side effects and tablet forms
Duration of treatment and chronic nature
Non-responders and lack of efficacy
Injection sites and needle anxiety
Combining GLP-1s with HRT
Reaching goal weight and stopping medication
Weight plateaus and muscle maintenance
Taking a break for holidays or events
Short-term use and weight regain risks
Pancreatitis risk and warning signs
Dosing frequency and the 'golden dose'
Listen ad-free on Castria