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GLP-1s: Your questions answered

Oct 22, 2026 · 17m

Summary

Professor Donald O'Shea, an obesity specialist, joins *Drive Time* to answer listener questions regarding the use, side effects, and long-term management of GLP-1 medications in Ireland. He addresses concerns about access through the Drugs Payment Scheme, the necessity of lifelong treatment for chronic obesity, and the importance of maintaining muscle mass to prevent frailty. The discussion also covers practical advice on injection sites, dosing schedules, and managing potential complications like pancreatitis.

Topics discussed

Introduction and listener questions Listener case: Severe obesity and cost barriers Access to Saxenda and future HSE decisions Side effects and tablet forms Duration of treatment and chronic nature Non-responders and lack of efficacy Injection sites and needle anxiety Combining GLP-1s with HRT Reaching goal weight and stopping medication Weight plateaus and muscle maintenance Taking a break for holidays or events Short-term use and weight regain risks Pancreatitis risk and warning signs Dosing frequency and the 'golden dose'
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