How Do You Kill a Mosquito?
Summary
This episode explores whether we should use CRISPR gene drives to eradicate mosquitoes, the world’s deadliest animal. Host Ben Bradford interviews biologist Kevin Esfeldt about the science, ecological risks, and ethical dilemmas of releasing engineered insects. The discussion covers the potential for unintended consequences, the need for global regulation, and historical precedents like sterile screwworm fly releases.
Topics discussed
Introduction: Mosquitoes as humanity's deadliest killer
CRISPR and gene drives: The technology behind eradication
Lab experiments: Engineering 'Jerry' the sterile mosquito
Ecological risks and the 'Jurassic Park' containment problem
Sponsors: Mattress Firm, IXL, and Viking Cruises
Historical parallels: Rabbits in Australia and New Zealand
Ethical dilemmas: Playing God and unintended consequences
Daisy-chain gene drives: A self-limiting safety mechanism
Field testing: Community consent and political hurdles in Africa
Global governance: The lack of international regulation
Precedent: Eradicating screwworm flies with radiation
Future targets: Schistosomiasis, locusts, and other pests
Conclusion: The moral weight of engineering nature
Listen ad-free on Castria