Rob Lowe discusses his four-decade career, attributing his longevity to risk-taking and a "healthy case of the fuck-its." He shares stories of failure, including his infamous Oscars opening number and a disastrous David Letterman appearance, to illustrate the importance of resilience. The conversation explores how the industry has shifted toward valuing authenticity, with Lowe arguing that making oneself "available" and owning flaws is more relatable than maintaining a perfect public image.
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